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In addition, we found that NAC treatment prevented THC-induced increases in the polyamine spermidine, which is known to regulate glutamatergic signaling by potentiating NMDA-receptor sensitivity to glycine [105]

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Interestingly, bioinformatic analyses conducted on bulk tissue data obtained from healthy human brain tissue donors revealed that endothelial cells and microglia were the predominant senescent cell types, driven by CDKN1A/p21WAF1/CIP1 (42) revealing potential differences in senescent cell types between healthy and diseased states

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