glutathione gas pH/glutathione-responsive release of SO2 induced superoxide radical accumulation for therapy of cancer GshT is required for glutathione

10.3181/00379727-215-44108 134 ValeW.SpiessJ.RivierC.RivierJ

Recent studies have demonstrated that in triple-negative breast cancer (TNBC), a substantial decrease in cancer cell GSH levels and a significant increase in cellular superoxide levels can be induced by the administration of a dual metabolic inhibitor of GLS and xCT (SLC7A11), which promotes apoptosis [46]

It was observed that the G2019S mutation in LRRK2 results in delayed mitochondrial arrest and increased phosphorylation of the RAB10 protein (at the threonine 73 site), which in turn leads to impaired PINK1/Parkin-mediated mitophagy (Wauters et al., 2020)

Its growing popularity among scientific institutions and laboratories reflects the ongoing commitment to understanding peptide-based approaches to weight and glucose management

Every temperature excursion above 8C degrades the peptide irreversibly

Gerrits E, Giannini LAA, Brouwer N, et al