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Imboden M, Rochat T, Brutsche M, Schindler C, Downs SH, Gerbase MW, et al

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Inhibition of p53 also activates autophagy (Wang et al

Cells drop into senescence in increasing amounts as we age, and its one of the leading theories on why humans grow old and die eventually, the number of cells that are dividing and renewing the body drop in proportion to the number of cells in senescence, leading to higher and higher numbers of dysfunctional cells (that can cause cancer or inflammation), and the human body degrades until it can no longer function and we die