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Pregnancy, breastfeeding, kidney disease, severe anemia, and neurologic symptoms may require closer follow-up

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Bile is essential for detoxification, digestion, absorption of fats and fat-soluble vitamins, and many more important body functions (12)

The combining clue may be also the particular effect on blood vessels as the follow-up of its cytoprotection capability (Robert, 1979

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While the energetic effects fade after 2 to 4 weeks, vitamin B12 itself continues to be stored in the liver and can remain available for years