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CO 2 can suppress histamine release in mast cells by increasing intracellular Calcium levels (ref)

doi: 10.1016/j.exger.2019.05.002

Rare variant analysis has revealed that loss-of-function mutations within activating transcription factor 4 (ATF4), a transcription factor responsible for the upregulation of serine synthesis under conditions of serine starvation, are associated with higher risk for PAH, which further suggests serine is closely related PAH

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doi: 10.1056/NEJMoa2212948 9 Serrano-PozoADasSHymanBT