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For instance, in mouse embryonic stem cells, targeted disruption of glucose-6-phosphate dehydrogenase, which is the rate-limiting enzyme in the pentose phosphate pathway, the predominant metabolic pathway for the generation of NADPH (a cofactor of GR), renders cells extremely sensitive to H 2 O 2 -induced cell death 34

As glutathione synthesis in the brain relies on cysteine availability, the neuronal transporter excitatory amino acid carrier 1 (EAAC1) plays a critical role in importing cysteine and glutamate

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That doesnt make it a universal answer

Loading Phase Initial period of higher-frequency dosing designed to build tissue concentrations quickly

Other Toxins Some metals can accumulate in the tubules of the kidney and cause functional and structural damage