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A 2025 meta-analysis of 7 RCTs (n=456) reported standardized mean differences of -0.72 for wrinkles (95% CI -1.02 to -0.42

These variations in DNA methylation may provide an explanation for the increased glucose intolerance, poorer beta cell function, and differences in cardiac anatomy and physiology in adults with a history of SAM [132, 133]

The Bottom Line Most gut health protocols are like bailing water out of a sinking boat - youre treating symptoms while the real leak continues

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