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99.5% (96.1% in most favoured regions) of the residues for mutant GSTP1 lie in allowed regions as revealed by Ramachandran plot indicating the reliability of the structures predicted

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In animal studies, P21 has been shown to boost levels of BDNF (brain-derived neurotrophic factor), thus promoting neurogenesis (nerve growth) and inhibiting the formation of Amyloid plaques and Tau proteins seen in Alzheimer's disease

It is also seen to have anticancer, anti-osteoarthritis immunomodulatory, anti-diabetic, antiparasitic, antioxidant, and neuroprotective properties (Bakrim et al