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Tumour microenvironment (TME)-targeted nanotherapy Reprogramming the TME is a critical direction in nanotherapy, with strategies including immune cell regulation and metabolic intervention

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doi: 10.1016/j.pharmthera.2017.11.006

Mice with signs of unrelated illness, abnormal baseline renal function, or technical failure during surgery/crystal injection were excluded from analysis

Weighted gene co-expression network analysis (WGCNA) identified genotype-driven, rather than treatment-driven, gene modules, highlighting distinct transcriptional architectures between WT and KO animals

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