Weaknesses of our study include reliance on self-reported symptoms and diagnoses such as cough and acute exacerbations of COPD, the transient nature of HHs on imaging, and our relatively small sample size
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O 2 can be released into phagosome and gets converted to different radical and non-radical derivatives, such as hydrogen peroxide (H 2 O 2 ), hypochlorous acid (HOCl), hydroxyl radical (OH