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While these high-throughput measurements allow for an indirect measurement of the molecular composition and structure of the RBC cm , analysis of the organization of the individual components requires high resolution biophysical techniques, such as high resolution microscopy (Mikhalyov and Samsonov, 2011
The Phase 3 TRIUMPH-4 data confirmed this trajectory
Cells cultured in low folate or treated with sub-IC50 concentration of methotrexate proliferated slower than the controls, and this fitness defect is completely blunted while culturing cells in galactose (Fig
There is also a potentially relevant interaction between VEGF and FGF-2, as synergistic action between these two factors has been reported in the literature
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