Higher levels of vascular endothelial growth factor (VEGF), MMPs, and reduced TIMPs have been observed in endometriotic lesions, serum, and peritoneal fluid from endometriosis patients (Zafrakas et al., 2020
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This creates feed-forward cycles that exacerbate cuproptosis: mtROS oxidize cytosolic GSH, releasing bound Cu, and may upregulate the copper importer CTR1 via pathways such as NF-B, increasing copper influx [65]
Chen and Gallie 2008)
Science 307 (5710), 720724 (2005)