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[PubMed: 30689447] (70 year old woman developed seizures within 30 minutes after mistakenly taking an industrial form of ALA [4500 mg] with metabolic acidosis, lactic acidosis [14.9 mmoL], decrease in platelets [140,000 decreasing to 73,000/uL], and hemodynamic instability, responding to supportive therapy within several days)

doi: 10.1016/j.pneurobio.2014.01.002 249 SchmidtP

This focused approach may enhance therapeutic outcomes, as glutathione reaches affected areas more efficiently

By improving liver function and reducing inflammation, some patients see improved metabolism

Teleanu DM, Niculescu A-G, Lungu II, Radu CI, Vladcenco O, Roza E et al (2022) An overview of oxidative stress, neuroinflammation, and neurodegenerative diseases

At 72 weeks, participants on 15mg lost an average of 22.5% body weight compared to 2.4% in the placebo group