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Abbreviations 3-MA: 3-Methyladenine ADSC: Adipose-derived stem cell DEG: Differentially expressed gene ROS: Reactive oxygen species LPOs: Lipid peroxides OGD: Oxygen and glucose deprivation MDA: Malondialdehyde SOD: Superoxide dismutase Fer-1: Ferrostatin-1 GSH: Glutathione H&E: Hematoxylin and eosin KEGG: Kyoto Encyclopedia of Genes and Genomes MRI: Magnetic resonance imaging NAC: N -Acetylcysteine Nec-1: Necrostatin-1 NS: Normal saline PBS: Phosphate-buffered saline qRT-PCR: Quantitative real-time polymerase chain reaction SD: Standard deviation TEM: Transmission electron microscopy References Smith P, Adams WP Jr, Lipschitz AH, Chau B, Sorokin E, Rohrich RJ, Brown SA

Several factors support long-term safety: Preserved pituitary function: Unlike exogenous GH, sermorelin doesn't suppress the pituitary

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