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In a casecontrol study, Massey et al

Commentary R.I.s harm-reduction hypocrisy harms public health Decreasing flavor options and increasing tax on wholesale price on e-cigarettes undermines adult smokers efforts to quit and turn to safer alternatives Non-combustible products like vapes, and oral nicotine pouches carry much less risk than traditional cigarettes

Part of that may be because Smalls was into tinkering around with scientific projects in his room

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The association between combustible/electronic cigarette use and stroke based on national health and nutrition examination survey