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Synthesis and antiproliferative activity of a series of novel 6-substituted pyrido[3,2-d]pyrimidines as potential nonclassical lipophilic antifolates targeting dihydrofolate reductase
Nagalekshmi R, Menon A, Chandrasekharan DK, et al
There was no indication of increased frequency of TEAEs with increasing renal or hepatic impairment
Not intended for direct intravenous injection without proper medication reconstitution or dilution
Ethical approval and consent to participate The current study was approved by the Ethics Committee of the Affiliated Fuyang Peoples Hospital of Anhui Medical University before data collection and analysis (No.2021-19)