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Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases

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Therefore, we performed pharmacokinetic studies of BPC157 in beagle dogs following single IV administration at a dose of 6 g/kg, single IM administration at doses of 6, 30, or 150 g/kg, and repeated IM administration at a dose of 30 g/kg for seven consecutive days

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Minor side effects were also observed, such as gastrointestinal symptoms including indigestion, flatulence, nausea and diarrhoea

10.3969/j.issn.1000-744X.2020.03.033 139 YiX