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E-cigarette use has skyrocketed In the United States, cardiovascular disease is responsible for about one-third of smoking-associated deaths in smokers, and secondhand smoke causes approximately 34,000 early deaths from heart disease each year in nonsmokers

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Increases in both byssinosis and bronchitis were attributed to cotton dust exposure and smoking in the cotton industry (Molyneux & Tombleson, 1970

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Kitteringham, Assessment of Enzyme Induction and Enzyme Inhibition in Humans: Toxicological Implications, Xenobiotica, November 1990;20(11):117185