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Now, the Mayo Clinic has certainly came a long way since then adopting their own functional medicine department

These cytokines, associated with activated polymorphonuclear leukocytes (PMNs) and their derived proteases, destroy newly developing tissue and degrade key growth factors

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Gingival crevicular fluid shows significantly reduced GSH concentrations and markedly elevated 4-HNE levels ( 2.4 The ferroptosis-inflammation vicious cycle drives chronic periodontitis Growing evidence indicates that ferroptosis can trigger inflammatory responses, while the inflammatory microenvironment further promotes ferroptosis, forming a self-amplifying vicious cycle that drives the persistent progression of chronic periodontitis

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