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E-cigarettes are the most commonly used tobacco product among middle and high school students

Another potential issue is moisture exposure, which may promote breakdown of the whole nicotine lozenge structure

Youth should not use or have access to tobacco or nicotine-containing products.

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Therefore, large-scale and longitudinal metagenomic studies on cohorts from different geographical regions are much needed to understand the underlying mechanisms of microbiome-associated dysbiosis and carcinogenicity