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Therefore, Erastin not only directly induces necroptosis but also amplifies its occurrence through the ROS generated during ferroptosis, establishing a synergistic interaction between ferroptosis and necroptosis

Furthermore, in colorectal cancer, ROS generated from inflammatory cells, such as neutrophils and macrophages, play a critical role in the progression of colorectal cancer by inducing DNA damage, promoting epithelial cell proliferation, and impairing apoptosis

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Indeed, glomerulosclerosis is prevalent in more than 70% of individuals aged 40 years and older, and its incidence tends to escalate with advancing age (Wiggins, 2012)

Collagen is essential for maintaining skin elasticity and firmness