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This study setting is increasingly used for determination of effects of dietary supplements including pine bark preparations ( have been documented for various pathophysiologic states such as cardiovascular diseases or diabetes mellitus and have been previously reviewed (47)

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Treatments are customized , and weekly or monthly doses may be recommended based on individual needs

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This discrepancy highlights a critical translational lesson: while animal models excel at isolating specific pathways, human depression arises from interconnected networks that demand multimodal treatment strategies

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