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Assessing the lung cancer risk reduction potential of cMRTPs before or soon after they are introduced into the market is hampered by (i) the absence of clinical risk markers that are predictive of future lung cancer development, (ii) the latency of lung cancer manifestation (decades of smoking), and (iii) the slow reduction in excess risk upon smoking cessation and a fortiori upon switching to a cMRTP

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Further, it will be important to measure how this HWL is perceived by cigarette smokers and non-smokers

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Smoking also increased insulin resistance, and this can lead to poor blood sugar control and increase your risk of developing complications from diabetes