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In cI, cleavage of NDUFS1 by caspase-3 inhibits cI activities, causing ROS production and collapse of mitochondria membrane potential

These are not cherry-picked responders

Age and Baseline GHK-Cu Levels Older individuals with lower baseline GHK-Cu levels (~80 ng/mL at age 60 vs ~200 ng/mL at age 20) may see more dramatic improvements because they are correcting a larger deficit

If patients are eating less and potentially consuming less B12-rich food, supplementing directly alongside the semaglutide injection ensures adequate intake without requiring a separate oral supplement

it's about pushing the boundaries of what's understood