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For example, curcumin has been evaluated in Phase II clinical studies in pancreatic cancer and colorectal cancer patients, where oral doses up to 8 g/day demonstrated acceptable safety but limited systemic exposure, highlighting pharmacokinetic challenges

Lancet 1977;2:432-434

This type of vaccines can serve as dual vaccines, targeting both the parasites and their vectors, in an integral approach of control

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It may potentially improve sleep quality, but more studies are needed