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Increased Gb3 expression and lipid accumulation in GLA-KO human iPSC kidney organoids Next, to determine the accumulation of Gb3, a main pathological mechanism in human Fabry disease 6,7 , confocal microscopy was performed, which revealed extensive accumulation of Gb3 in podocytes and tubular cells in GLA-mutant human iPSC kidney organoids (Fig
5 Potential oxidative stress-related therapeutic targets in gastric cancer Regulation of redox homeostasis is crucial because increasing oxidative stress has a role in all stages of carcinogenesis either initiating/stimulating tumorigenesis and promoting cancer cells transformation/proliferation or leading to cell death
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Specifically, upregulation of the CCR8 signaling pathway promotes the activation of Tregs, reinforcing immunosuppression in the TME and disrupting the dynamic balance between Th17 and Treg cells (80)