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Thus, SARS-CoV-2 infection dysregulates mitochondrial metabolism and forces the host cell to generate energy (ATP) and other metabolites to support viral life cycle 38

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The pathophysiological significance of SIRT1 depends on the specific cellular context, particularly in a complex, multi-cellular disease such as MASLD

doi: 10.1016/j.ecoenv.2019.04.041 235 WeiS.WangX.ZhaoX.ZhaoK.XuL.ChenY

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