Despite their efficacy, long-term LD use is associated with motor complications, prompting the development of novel therapies such as adenosine A2A antagonists (istradefylline), which reduce OFF episodes, and GLP-1RAs, which show neuroprotective potential
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[27] Septic-shock and ARDS protocols use 0.1 mg/kg daily up to ten days, whereas perioperative antiemetic regimens commonly employ a single 4-10 mg IV bolus at induction, capitalizing on rapid onset ( 95 % potency retention for dexamethasone sodium phosphate vials stored 20-25 C and shielded from intense light for 91 days
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