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doi: 10.1016/j.tem.2015.07.001 272 XuLYinYLiYChenXChangYZhangHet al
155 Furthermore, GDH-derived NADPH is consumed to support the reductive carboxylation of -KG by IDH2, and the compensatory increase in the expression of GDH1 or GDH2 promote the growth of IDH-mutant glioma cells
In rat studies, administration of 10 mcg per kg per day for seven days produced region-specific increases in serotonin synthesis
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