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After over 50 years of monoaminergic-targeted antidepressants, approval of glutamate-targeted therapies represents an important new mechanism for depression treatment

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doi: 10.1016/j.bioorg.2024.107574 491 KunnumakkaraABAnandPAggarwalBB

The comparison that matters most is this: Selank demonstrates anxiolytic effects comparable to benzodiazepines without producing sedation, amnesia, withdrawal symptoms, or physical dependence