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Biomarkers such as CYP370A13 expression, glutathione depletion, and oxidative stress serve as sensitive indicators of APAP exposure

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Adipocyte overexpression of PNPLA2 protected mice from weight gain on chow and HFD, decreased adipocyte size and increased FAO and turnover of TAG (238), supporting the cause for stimulating lipolysis therapeutically

Glutathione acts as an endogenous antioxidant and detoxification molecule

Although a recent trial has shown to be beneficial when antiviral treatment is introduced early during the disease before hospitalization than later in the course of the disease, there is an urgent need for early therapies to reduce the risk of disease progression, prevent transmission, and be widely distributed to meet the worldwide demand (Gottlieb et al., 2022