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1 vial of Vitamin C

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The phase 2 study (ESTIMATE) showed similar results, with a mean increase in hemoglobin level of 1.3 g/dL and 1.1 g/dL during the 8-week dose finding and the 1-year fixed-dose extension period, respectively, 30,31 as well as a significant increase in ATP and reduction in 2,3-DPG, hemolytic markers, p50, and point of sickling during the extension period, presented as a conference abstract

PMC 1560398