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Recently, it was also found that plant extracts can regulate microglia to express the M2 phenotype more than the M1 phenotype (Yang et al., 2017) to reduce neuroinflammation and nerve cell damage and to clear A (Figure 2)

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Some gut pathogens, such as Aquabacterium, Peptococcus , and Sphingomonas , have been associated with motor complications in PD (Qian et al., 2018)