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Musculoskeletal: Arthralgia, jaw and extremity growth, increased intracranial pressuredocumented adverse effects from mecasermin therapy in pediatric patients

Receptor Grade IGF-1 LR3 and Metabolic Activity Studies (7) have suggested that IGF-binding proteins, including Receptor Grade IGF-1 LR3, may have the potential to induce glucose uptake and, thereby, glucose metabolism through the possible activation of signaling mechanisms

However, its worth noting that these potential positive outcomes are gradual, happening over weeks or months of continued use

Measurement of Serum 8-OHdG and GGT Levels We measured serum 8-OHdG and GGT as previously described

consistently for at least one month for the best results

Park HJ, Yang SG, Koo DB