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In the NC group, histological analysis revealed a dense accumulation of melanin granules throughout the epidermis, resulting in pronounced dark pigmentation

The structures of TyrBm with bound inhibitors were solved by molecular replacement using Phaser 53 and the coordinates of earlier determined TyrBm structure (PDB code 4P6R)

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So dose/volume tunes you from ~50% 70% 5AR2 inhibition locally, with varying systemic spillover

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