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They are the norm when people self-administer based on internet forums and social media advice

Transdermal delivery patches, gels, creams bypasses the liver entirely, which may offer a more favorable cardiovascular and clotting profile for many patients

doi:10.1016/bs.apha.2018.12.004 Su W, Zhang Y, Zhang Q, et al

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T., Talalay P., Sharkey J., et al