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Together, the beneficial action is going on both centrally and peripherally, overwhelming both central and peripheral harms of the permanent central venous occlusion

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However, high concentrations of NO and heat-induced nitric oxide synthase (iNOS), an enzyme involved in the production of NO, have been shown to be increased in infertile patients compared to fertile ones and responsible for sperm DNA damage and decreased sperm motility [57,58]

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