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LTP in these cells could be induced by high-frequency burst stimulation only if the stimuli were weak or paired with hyperpolarization of the postsynaptic cell (Lamsa et al., 2007)

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That shared regulatory status doesn't resolve the route question above it just means neither form has cleared the trial process required for an approved drug label

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Other proposed contributors discussed in the literature include modulation of the dopaminergic and serotonergic systems, growth hormone receptor expression in fibroblasts, and interaction with the nitric oxide system at the level of vasomotor regulation (Sikiric et al., 2018)