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Under oxidation conditions, TRPV1 can overexpress tumor necrosis factor receptor 1 (TNFR1) in DRG cells through a ROS-mediated signaling pathway, which could bind with proinflammatory cytokine tumor necrosis factor (TNF-) to increase inflammatory conditions and nociception (Westlund et al., 2010)

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In addition, poor sleep quality such as that associated with obstructive sleep apnea may increase risk by interfering with blood flow to the brain and normal patterns of brain activity that promote memory and attention