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To produce a DBS sample, a small skin puncture (typically from a fingertip or heel) is made, a drop of blood is applied directly onto the filter paper to fully saturate a marked area, and the card is left to air-dry before packaging

When in doubt, throw it out

A degraded lyophilised vial may appear yellowish rather than white, may fail to dissolve despite adequate water and time, or may produce a yellow-tinted solution

Others may notice gradual improvement over the first few days

Wipe both stoppers with alcohol, add bacteriostatic water down the inside glass wall, swirl until clear without shaking, and refrigerate for 46 weeks

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