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60,000 for a 12m period

This led to the introduction of packs of 25s in 1976 by Rothmans Pty Ltd for its Winfield brand, and then packs of 30s, 40s, and 50s throughout the 1980s and 1990s by all of the major tobacco companies across numerous brands

When antibiotics are needed, a doctors prescription is required

the quality of the tobacco in the cigarette

Cartons themselves are not tightly regulated, but every pack inside them must comply with Canadian tobacco laws, including labelling and minimum size

Perhaps a more important limitation is that all the participants were current or former cigarette smokers, and only 165 used e-cigarettes exclusively