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The implication for clinical practice is that restoring youthful MOTS-c signaling might be a mechanistically legitimate target for longevity intervention

Complementary Peptide Therapies Can be effectively paired with systemic peptides that support overall metabolism and weight management for comprehensive body composition optimization

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This finding does not establish causality, but it is consistent with a model in which robust mitochondrial peptide signaling is a feature of successful aging rather than a peripheral correlate