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Both cell lines exhibited a notable decrease in TXNIP expression after treatment with biguanides, including metformin, phenformin and buformin (Fig

BioDrugs, 12 , 139-157

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Immunostaining revealed mixed cell populations with many undifferentiated hPSCs and mesoderm cells, and DE markers SOX17 and FOXA2 were expressed at lower levels compared to the Activin A-based control (CA)