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To further investigate the quantity and activation status of microglia in the hippocampus, we labeled them using IBA1 and CD68

These reprogrammed macrophages contribute to enhanced lung metastasis, and circulating levels of exosomal miR-138-5p have been positively associated with disease progression in patients [61]

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3.6 Gut-cancer axis Imbalance in gut microbiome can lead to chronic inflammation and this sustained inflammatory response can damage DNA in cells, which may initiate tumor development