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This impairs the activity of glutathione peroxidase 4 (GPx4), which specifically reduces lipid hydroperoxides of PUFAs to the respective lipid alcohol and thereby interrupts the propagation of LPO [63]

+ H tr tng cng kh nng chng oxy ha + Ci thin tnh trng suy gim ni tit t n + Hn ch lo ha da + Gim nm, vt nhn, sm da, lm p da Vin ung Glutathione 600 gi 580.000 Cch ung Glutathione 600

21 , 22 This process requires the presence of H 2 O 2 as an oxidizing agent catalyzed by thyroid peroxidase (TPO) in the thyroid and by lactoperoxidases (LPO) in the breast (Figure 1)

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[31] It is the precursor of phytochelatins, glutathione oligomers that chelate heavy metals such as cadmium