We devised an endosome-escaping HLAH peptide by replacing K in KLAK peptide with H (Fig
Unlike signal peptides (e.g., palmitoyl pentapeptide-4) that primarily stimulate collagen synthesis, or carrier peptides (e.g., manganese tripeptide-1) that facilitate mineral transport, GHK-Cu functions as a copper transporter with direct antimicrobial activity
Hippocampus and nitric oxide
Penetratin, a cationic CPP (RQIKIWFQNRRMKWKK) with a hydrophobic and amphipathic nature, is derived from Drosophila homeodomain and is mainly internalized into cells via macropinocytosis ( in vivo ( in silico analysis identified the moieties essential for penetratins carrier ability and the variants, including shuffle (R,K fix) 2 ( via the interaction between L-penetratin and plasma membrane ( Since penetratin has the disadvantages that relatively high doses of penetratin are required for nasal insulin absorption ( Additional in silico analysis using molecular orbital study with self-organizing map (SOM) classification, identified the novel penetratin analog named PenetraMax (KWFKIQMQIRRWKNKR) ( It was suggested that improved efficiency of Shuffle (R,K fix) 2 and PenetraMax is due to the rearrangement of hydrophobic Trp residues (Lensink et al., 2005
supplementation before and during pregnancy to reduce the risk of neural tube defects
Epidemiology of autism in adults across age groups and ability levels
