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In preclinical models these pathways translate into neuroprotection against amyloid-beta toxicity by preserving mitochondrial membrane potential and blocking apoptosis [3] , and into metabolic effects centrally-mediated improvements in insulin sensitivity and lower blood glucose in rodent studies [2]

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Various versions of HT have been reported with various HLA alleles, including DR3, DR5, DQ7, DQB1*03, DQw7, or the DRB1*04-DQB1*0301 haplotype