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Recently, a structure-based screening has led to the discovery of the first NAPRT activators based on 1,2-dimethylbenzimidazole scaffolds 231 , but evidence for these compounds in boosting NAD + metabolism is still lacking

Notably, ATM signaling plays a critical role in coordinating DDR by phosphorylating key substrates involved in DNA repair, checkpoint activation, and apoptosis (Lee, 2024)

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D., Triantafyllou, K