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doi:10.1074/jbc.M008212200

Urea and uric acid can safely diffuse into the blood and then be excreted in urine

US patent 0337024, Allison Coffin, Joseph Harding, Leen Kawas, Phillip Uribe, "Novel Lead Compound for Otoprotection: Targeting HGF Signaling with Dihexa", issued 2015-11-26 "Dihexa" (PDF)

Other groups found similar outcomes that linked the GPx3 locus to ALS but were also able to demonstrate that lower GPx3 levels strongly correlated with more advanced disease, in addition to showing significant motor deficits in a knockdown zebra fish model 21

Understanding their differences helps clarify their potential applications

To accomplish this, researchers used 32 male New Zealand white rabbits, each 12 weeks old