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Common treatment areas include the forehead, between the brows (frown lines), crow's feet, and the area around the mouth

Emphasis was placed on studies that clearly delineated molecular pathways or therapeutic effects, with priority given to those with translational relevance

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14,15 Once released into the circulation, GH binds and activates the cell-surface GHR, as well as the related prolactin receptor in target tissues such as liver, muscle, bone, and adipose tissue (Fig